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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Medicina / Medicine (M001)
Author(s): Grikinienė, Jurgita;Stakišaitis, Donatas;Jankūnas, Rimas Jonas;Uleckienė, Saulė;Obelenienė, Birutė
Title: Gender-related differences in urinary excretion of magnesium in adolescents receiving valporate
Is part of: Trace elements and electrolytes. Deisenhofen-Muenchen: Dustri-Verlag Dr. Karl Feistle, 2011, vol. 29, no. 1
Extent: p. 48-53
Date: 2011
Keywords: Valproate;Magnesium;Urine;Adolescents;Epilepsy;Gender
Abstract: Background: Valproates (VPA) are known to increase diuresis and urinary excretion of sodium and chloride in both genders of rats. Magnesiuretic effect of VPA was investigated in rats. Several tests have shown gender-related differences in ion transport across cell membrane and their urinary excretion. Aim of the study: To find peculiarities of urinary magnesium (Mg2+) excretion in epileptic adolescents receiving VPA and to elucidate gender-related differences. Materials and methods: We monitored 24-h urinary levels of Mg2+ and creatinine as well pH in 47 epileptic adolescents receiving VPA and 95 controls. Results: Diurnal, nocturnal and 24-h urinary Mg2+ excretion in VPA-treated epileptic girls was significantly higher than in controls. Nocturnal diuresis in VPA-treated epileptic girls was significantly higher than in controls. Such differences were not found in epileptic boys receiving VPA. Conclusion: VPA may precipitate disturbance of Mg2+ homeostasis. VPA-induced disturbance of Mg2+ homeostasis may be gender-related
Affiliation(s): Lietuvos sveikatos mokslų universitetas
Mykolo Romerio universitetas
Teologijos katedra
Vilniaus univerasiteto Onkologijos institutas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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