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Type of publication: Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Biofizika / Biophysics (N011)
Author(s): Tiwari, Kumar Anubhav;Maciulevičius, Martynas;Raišutis, Renaldas;Chopra, Sonam;Navickaitė, Diana;Šatkauskas, Saulius
Title: Estimation of microbubble survival time for sonoporation temporal dosimetry by signal processing
Is part of: Open readings 2020: 63nd international conference for students of physics and natural sciences, March 17-20, 2020, Vilnius, Lithuania: abstracts book. Vilnius : Vilnius University, 2020
Extent: p. 96-96
Date: 2020
ISBN: 9786090703779
Abstract: The microbubbles (MBs) are ultrasound (US) contrast agents, which are used to improve the visibility in diagnosis by contrast imaging techniques. Moreover, in the therapeutic applications of sonoporation, it causes a significant reduction of acoustic cavitation threshold. In the cell sonoporation phenomenon, the microbubble (MB) cavitation results due to the interaction of MBs with US. At low acoustic pressure, MB stable cavity (MB-SC) exists and MB acts as a linear system exhibiting linear and periodic oscillations in response to the ultrasonic excitation. In this state, scattered US is generated comprising the harmonic, subharmonic and ultra harmonic spectral contents of the fundamental frequency [1]. However, at higher acoustic pressures, the MBs oscillate and continuously grow in size until the drastically implosion. In this transitional state, the cavitation is called as MB inertial cavitation (MB-IC). This phenomenon leads to introduce the broadband noise in the scattered spectrum, which can be used for the quantification of MB-IC extent. The explosion of MB exhibits various physical effects such as sudden temperature increase, microjets, shock waves, etc. In order to form sonoporation an effective and controllable drug delivery system in the temporal and spatial domain, one of the prime necessities is the development of an adequate and precise MB-IC dosimetry system [2, 3]. The objective of this work is to apply the signal processing approach for the estimation of optimal value of MB exposure time in order to achieve the maximum sonoporation efficiency with high cell viability. During the experiment, sonoporation cuvette of 1 cm path-length is used. It was filled either by 1 ml of MB suspension (+MB) or 1 ml of the phosphate-buffered saline-background group (MB-). The US waves were excited by an ultrasonic transducer having center frequency of 1 MHz and bandwidth up to 1.2 MHz (– 6 dB)[...]
Affiliation(s): Biologijos katedra
Gamtos mokslų fakultetas
Kauno technologijos universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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