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Type of publication: Konferencijų tezės nerecenzuojamuose leidiniuose / Conference theses in non-peer-reviewed publications (T2)
Field of Science: Fizika / Physics (N002)
Author(s): Karalius, Nerijus;Lapeika, Vytautas;Tamulienė, Jelena;Rastenienė, Loreta;Vaišnoras, Donatas Rimantas
Title: Stem cells adhesion by functionalized nanodiamonds
Is part of: Molecular biophysics – ABC of the puzzle of Life: 3rd ARBRE-MOBIEU COST action plenary meeting, Zagreb, March 18-20, 2019: book of abstracts. Zagreb: Ruđer Bošković Institute, 2019
Extent: p. 100-100
Date: 2019
Keywords: Nanodiamond;Stem cells
ISBN: 9789537941284
Abstract: Cells are surrounded by extracellular matrix in their natural environment [1]; nanoscale topography is observed on the extra–cellular matrix surface. The understanding of these nano–cell interactions is essential if advances in knowledge about cell motility, morphology, proliferation and differentiation are to occur [2]. In this report the interaction between nanodiamond nanoparticles, size 5 nm and human stem cells has been investigated. It has been shown that nanodiamonds with oxygen containing groups on the surface allow for a significantly better stem cells attachment over hydrogen functionalization. Nanodiamonds surface modification by oxygen demonstrate strong resonant as negatively charged structures and strong conjugate with the positively charged extracellular matrix. Contact angle measurements and protein adsorption experiments have enabled the development of a probable explanation as to why this difference is observed. As extracellular matrix used both mixture of the cyanobiphenyl organic compound where banana-shaped molecules (2x0,5 nm) and ball shaped the PPI dendrimer molecules where well oriented around nanodiamond to onion or ball structures, as illustrated in Figure1
Affiliation(s): Edukologijos tyrimų institutas
Mokytojų rengimo institutas
Vilniaus universitetas
Vytauto Didžiojo universitetas
Švietimo akademija
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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