Synthesis and bio-investigation of novel bipirazole derivatives

Abstract

The progress of the pharmaceutical industry depends on new biologically active substances availability. Despite the widespread interest in pyrazole chemistry, many unresolved challenges remain, such as the synthesis and biotesting of polycyclic pyrazole derivatives. Based on this, the concept of current work was formulated: the development of novel bipyrazole derivatives synthetic procedures and their applicability in anticancer therapy. Pyrazole and hydrazone derivatives possess broad spectra of biological characteristics ranging from antioxidant, anti-inflammatory, antiviral effects activity and other [1-2]. The bipyrazole system could not only improve the biological effects of compounds already possessing a pyrazole ring but also provide a new asset of pharmacologically desired properties [3]. In search of a condensation reaction for the bipyrazole system, various methods were tested. It was found, that sodium nitrite catalyzed cyclization of pyrazole-hydrazones proved to provide the highest yield of the target bipyrazole. The effect of synthesized bipyrazole derivatives on cell viability was investigated.