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Type of publication: conference paper
Type of publication (PDB): Straipsnis nerecenzuojamoje Lietuvos konferencijos medžiagoje / Article in non-peer-reviewed Lithuanian conference proceedings (P2c)
Field of Science: Chemija / Chemistry (N003)
Author(s): Bironaitė, D;Gefenas, Vladas
Title: N- ir O-etoksikarbonilmetilintų pirimidinonų sintezė bei antileukeminis aktyvumas
Other Title: Synthesis and antileukemic activity of N- and O-ethoxycarbonylmethylatedpyrimidinones
Is part of: Organinė chemija : mokslinės konferencijos "Chemija ir cheminė technologija" pranešimų medžiaga = Organic chemistry : proceedings of scientific conference "Chemistry and chemical technology" / Kauno technologijos universitetas. , 2011
Extent: p. 115-116
Date: 2011
Abstract: In continuing our study of the alkylation of 2(1//)- and 4(3//)-pyrimidinones we report here the synthesis and antileukemic properties of novel O-, N(3)- and N(l)-ethoxycarbonylmethylated 5-cyano-2-ethylsulfanyl-4(3//)-pyrimidinones. The interaction of 5-cyano-2-ethylsulfanyl-4(3//)-pyrirnidinone with ethyl bromoacetate was carried out in the presence of potassium carbonate in anhydrous acetonitrile medium. Various concentrations of all tested O- and N-alkylated pyrimidinone derivatives significantly (40-80 %) caused apoptosis in HL-60, promyelocytic leukemia cells line for studies of leukemia in vitro. The most effective compound was Af-alkylated derivative 3 (IC50 = 200 |oM, 24 h treatment). The possible molecular mechanism of anti-cancer action of these compounds is under investigation
Affiliation(s): Vytauto Didžiojo universitetas
Švietimo akademija
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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