Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/54702
Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Chemijos inžinerija / Chemical engineering (T005)
Author(s): Kaya, Murat;Akyuz, Bahar;Bulut, Esra;Sargin, Idris;Tan, Gamze;Erdonmez, Demet;Maheta, Mansi;Šatkauskas, Saulius;Mickevičius, Saulius
Title: DNA interaction, antitumor and antimicrobial activities of three-dimensional chitosan ring produced from the body segments of a diplopod
Is part of: Carbohydrate polymers. Amsterdam, Netherlands : Elsevier, 2016, Vol. 146
Extent: p. 80-89
Date: 2016
Keywords: Millipede;Chitin;Biopolymer;Cytotoxicity;HeLa cell line;Antibacterial
Abstract: Commercially available chitins and the chitin isolated from mushrooms, insect cuticles, shells of shrimp, crab and crayfish reported in the literature are in forms of powder, flake or granule. Threedimensional chitins have been only known from the sponges but still threedimensional chitosan has not been reported yet. In this study, we produced threedimensional chitin and chitosan rings from the body segments of a diplopod species (Julus terrestris). Obtained chitin and chitosan rings were characterized (by FTIR, SEM, TGA, XRD, dilute solution viscometry and EA) and compared with commercial chitin and chitosan. The interactions with plasmid DNA was studied at varying concentrations of chitosan (0.04, 0.4 and 4 mg/mL). Antitumor activity tests were conducted (L929 and HeLa), low cytotoxicity and high antiproliferative activity was observed. Antimicrobial activities of J. terrestris chitosan were investigated on twelve microorganisms and maximum inhibition (15.6 ± 1.154 mm) was recorded for common human pathogen Staphylococcus aureus
Internet: https://doi.org/10.1016/j.carbpol.2016.03.033
Affiliation(s): Biologijos katedra
Fizikos katedra
Gamtos mokslų fakultetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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