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dc.contributor.authorKogevinas, Manolis-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorGracia-Lavedán, Esther-
dc.contributor.authorBallester, Ferran-
dc.contributor.authorCordier, Sylvaine-
dc.contributor.authorCostet, Nathalie-
dc.contributor.authorEspinosa, Ana-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorDanilevičiutė, Asta-
dc.contributor.authorIbarluzea, Jesus-
dc.contributor.authorKaradanelli, Maria-
dc.contributor.authorKrasner, Stuart W-
dc.contributor.authorPatelarou, Evridiki-
dc.contributor.authorStephanou, Euripides G-
dc.contributor.authorTardón, Adonina-
dc.contributor.authorToledano, Mireille-
dc.contributor.authorWright, John-
dc.contributor.authorVillanueva, Cristina M-
dc.contributor.authorNieuwenhuijsen, Mark-
dc.descriptioneISSN 1531-5487-
dc.description.abstractBackground: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002–2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case–control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene–environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. [...]en
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 903-911-
dc.relation.ispartofEpidemiology. Philadelphia : Lippincott Williams & Wilkins, 2016, Vol. 27, no. 6-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyCINAHL Complete (EBSCO)-
dc.relation.isreferencedbyIndex Medicus-
dc.subjectWater disinfectionen
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titleDrinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a European mother–child cohort studyen
dc.typeresearch article-
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