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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Kogevinas, Manolis;Bustamante, Mariona;Gracia-Lavedán, Esther;Ballester, Ferran;Cordier, Sylvaine;Costet, Nathalie;Espinosa, Ana;Gražulevičienė, Regina;Danilevičiutė, Asta;Ibarluzea, Jesus;Karadanelli, Maria;Krasner, Stuart W;Patelarou, Evridiki;Stephanou, Euripides G;Tardón, Adonina;Toledano, Mireille;Wright, John;Villanueva, Cristina M;Nieuwenhuijsen, Mark
Title: Drinking water disinfection by-products, genetic polymorphisms, and birth outcomes in a European mother–child cohort study
Is part of: Epidemiology. Philadelphia : Lippincott Williams & Wilkins, 2016, Vol. 27, no. 6
Extent: p. 903-911
Date: 2016
Note: eISSN 1531-5487
Keywords: Water disinfection;Pregnancy;Trihalomethanes
Abstract: Background: We examined the association between exposure during pregnancy to trihalomethanes, the most common water disinfection by-products, and birth outcomes in a European cohort study (Health Impacts of Long-Term Exposure to Disinfection By-Products in Drinking Water). We took into account exposure through different water uses, measures of water toxicity, and genetic susceptibility. Methods: We enrolled 14,005 mothers (2002–2010) and their children from France, Greece, Lithuania, Spain, and the UK. Information on lifestyle- and water-related activities was recorded. We ascertained residential concentrations of trihalomethanes through regulatory records and ad hoc sampling campaigns and estimated route-specific trihalomethane uptake by trimester and for whole pregnancy. We examined single nucleotide polymorphisms and copy number variants in disinfection by-product metabolizing genes in nested case–control studies. Results: Average levels of trihalomethanes ranged from around 10 μg/L to above the regulatory limits in the EU of 100 μg/L between centers. There was no association between birth weight and total trihalomethane exposure during pregnancy (β = 2.2 g in birth weight per 10 μg/L of trihalomethane, 95% confidence interval = 3.3, 7.6). Birth weight was not associated with exposure through different routes or with specific trihalomethane species. Exposure to trihalomethanes was not associated with low birth weight (odds ratio [OR] per 10 μg/L = 1.02, 95% confidence interval = 0.95, 1.10), small-for-gestational age (OR = 0.99, 0.94, 1.03) and preterm births (OR = 0.98, 0.9, 1.05). We found no gene–environment interactions for mother or child polymorphisms in relation to preterm birth or small-for-gestational age. [...]
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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