Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/50652
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dc.contributor.authorMaciulevičius, Martynas-
dc.contributor.authorTamošiūnas, Mindaugas-
dc.contributor.authorJurkonis, Rytis-
dc.contributor.authorVenslauskas, Mindaugas Saulius-
dc.contributor.authorŠatkauskas, Saulius-
dc.coverage.spatialUS-
dc.date.accessioned2018-10-06T22:50:15Z-
dc.date.available2018-10-06T22:50:15Z-
dc.date.issued2015-
dc.identifier.issn15438384-
dc.identifier.otherVDU02-000018786-
dc.identifier.urihttps://hdl.handle.net/20.500.12259/50652-
dc.description.abstractUltrasound induced microbubble (MB) cavitation is used to significantly enhance cell membrane permeabilization, thereby allowing delivery of various therapeutic agents into cells. In order to monitor and quantitatively control the extent of cavitation the uniform dosimetry model is needed. In present study we have simultaneously performed quantitative evaluation of three main sonoporation factors: (1) MB concentration, (2) MB cavitation extent, and (3) doxorubicin (DOX) sonotransfer into Chinese hamster ovary cells. MB concentration measurement results and passively recorded MB cavitation signals were used for MB sonodestruction rate and spectral root-mean-square (RMS) calculations, respectively. Subsequently, time to maximum value of RMS and inertial cavitation dose (ICD) quantifications were performed for every acoustic pressure value. This comprehensive research has led not only to explanation of relation of ICD and MB sonodestruction rate but also to the development of a new sonoporation metric: the inverse of time to maximum value of RMS (1/time to maximum value of RMS). ICD and MB sonodestruction rate intercorrelation and correlation with DOX sonotransfer suggest inertial cavitation to be the key mechanism for cell sonoporation. All these metrics were successfully used for doxorubicin sonotransfer prediction (R2 > 0.9, p < 0.01) and therefore shows feasibility to be applied for future dosimetric applications for ultrasound-mediated drug and gene deliveryen
dc.description.sponsorshipBiochemijos katedra-
dc.description.sponsorshipBiologijos katedra-
dc.description.sponsorshipKauno technologijos universitetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 3620-3627-
dc.language.isoen-
dc.relation.ispartofMolecular pharmaceutics. Washington: ACS Publications, 2015, vol. 12, iss. 10-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyMEDLINE-
dc.relation.isreferencedbyScopus-
dc.subjectSonoporacijalt
dc.subjectDoksorubicinaslt
dc.subjectMikroburbulų nykimo greitislt
dc.subjectInercinės kovitacijos dozėlt
dc.subjectSonoporationen
dc.subjectMetricen
dc.subjectDoxorubicinen
dc.subjectMicrobubble sonodestructionen
dc.subjectInertial cavitation doseen
dc.subject.classificationStraipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)-
dc.subject.otherBiofizika / Biophysics (N011)-
dc.titleAnalysis of metrics for molecular sonotransfer in vitroen
dc.typeresearch article-
dc.identifier.doihttps://doi.org/10.1021/acs.molpharmaceut.5b00347-
dc.identifier.isiWOS:000362460500012-
dcterms.bibliographicCitation45-
dc.date.updated2020-01-29T14:57Z-
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local.typeS-
item.fulltextWith Fulltext-
item.grantfulltextopen-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptTarptautinių ryšių departamentas-
crisitem.author.deptBiologijos katedra-
crisitem.author.deptBiologijos katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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