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Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Sutkuvienė, Simona;Mikalayeva, Valeryia;Pavan, Sylvia;Berti, Federico;Daugelavičius, Rimantas
Title: Evaluation of the efficiency of synthesized efflux pump inhibitors on salmonella enterica ser. Typhimurium cells
Is part of: Chemical biology and drug design. Oxford : Wiley-Blackwell, Vol. 82, iss. 4, 2013
Extent: p. 438-445
Date: 2013
Note: Online ISSN: 1747-0285
Keywords: RND tipo daugiavaisčio atsparumo siurbliai;Salmonella enterica;Dipeptidai;Slopikliai;Dipeptide;Inhibitor;RND-type efflux pumps;Salmonella enterica
Abstract: Multidrug efflux pump inhibitors have a great potential as pharmacological agents that increase the drug susceptibility of bacterial pathogens. Our study was focused on the synthesis and evaluation of the efficiency of resistance–nodulation–division (RND) family efflux pump inhibitors. The efficiency of these inhibitors was investigated on Salmonella enterica ser. typhimurium cells using tetraphenylphosphonium (TPP+) and ethidium cations as the efflux pump substrates. Results of our study indicated that efficiency of the inhibitors depends on the cell outer membrane permeability and method of the assay used. Temperature of the incubation medium and a solvent of the inhibitor used have only minor effect on results of the assay
Affiliation(s): Biochemijos katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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