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Type of publication: research article
Type of publication (PDB): Straipsnis recenzuojamoje Lietuvos tarptautinės konferencijos medžiagoje / Article in peer-reviewed Lithuanian international conference proceedings (P1e)
Field of Science: Biologija / Biology (N010)
Author(s): Marandykina, Alina;Zablockaitė, Danguolė;Buzaitė, Odeta;Treinys, Rimantas;Bogdelis, Andrius;Jurevičius, Jonas;Skeberdis, Vytenis Arvydas
Title: β3-adrenergic receptor polymorphism-dependent regulation of L-type calcium current and force of contraction in human atrium
Is part of: The Vital Nature Sign : 3rd International Conference, Kaunas, Lithuania, May 22-23, 2009 : proceedings. Kaunas : Vytautas Magnus university, 2009
Extent: p. 128-129
Date: 2009
Keywords: β3-adrenergic;L-type calcium current;Human atrium
ISBN: 9789955125426
Abstract: β3-adrenergic receptor (β3-AR) agonists stimulate L-type Ca2+ current (ICa,L) and force of contraction in human atrium [1]. Contraction force of the heart muscle depends on Ca2+ ion current through L-type calcium channels in plasma membrane of single myocytes, which is predominantly regulated by β-adrenergic receptors and cAMPdependent phosphorylation [2]. One nonsynonymous single nucleotide polymorphism Trp64Arg of β3-AR has been reported, which causes weaker cAMP accumulation comparing to Trp64Trp one [3]. Therefore, we examined a role of β3-AR polymorphism in β3-AR agonist CGP12177 and BRL37344 induced stimulation of ICa,L and contraction force in isolated human atrial myocytes and atrial trabeculae, respectively. [...]
Affiliation(s): Gamtos mokslų fakultetas
Kauno medicinos universiteto Kardiologijos institutas
Kauno medicinos universiteto Kardiologijos institutas,
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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