Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/37622
Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biochemija / Biochemistry (N004)
Author(s): Jarmalavičienė, Reda;Szumski, Michał;Kornyšova, Olga;Kłodzińska, Ewa;Westerlund, Douglas;Krawczyk, Stanislas;Mickevičius, Donatas;Buszewski, Boguslaw;Maruška, Audrius
Title: Coupling of solid-phase microextraction continuous bed (monolithic) capillaries with capillary zone electrophoresis for direct analysis of drugs in biological fluids
Is part of: Electrophoresis. Special iss: a luminary separation scientist. Weinheim : Wiley-VCH Verlag GmbH & Co., Vol. 29, iss. 8 (2008)
Extent: p. 1753-1760
Date: 2008
Keywords: Biological fluids;Capillary zone electrophoresis;Continuous beds;Monoliths;Restricted-access media
Abstract: Hyperlink robust biocompatible solid-phase microextraction (SPME) devices were prepared using continuous bed (monolithic) restricted-access media (RAM) as the SPME capillary insert The RAM-based SPME approach was able to simultaneously separate proteins from a biological sample, while directly extracting the active components of caffeine, paracetamol and acetylsalicylic acid from the drug NeoCitramonum. The devices were interfaced with a CZE system and fully automated analysis for sample preconcentration, desorption, separation and quantification of analytes was evaluated. Comparative study of in-line coupled SPME-CZE using RAM and RP capillary inserts was carried out. Using an SPME (RAM) insert, the calculated caffeine, paracetamol and acetylsalicylic acid LODs in a bovine plasma sample were 0.3, 0.8 and 1.9 ng/mL, respectively
Internet: https://onlinelibrary.wiley.com/doi/epdf/10.1002/elps.200800046
Affiliation(s): Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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