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Type of publication: Straipsnis / Article
Author(s): Šatkauskas, Saulius;Tamošiūnas, Mindaugas;Maciulevičius, Martynas;Venslauskas, Mindaugas Saulius;Jurkonis, Rytis
Title: Sonoporation dosimetric evaluation from ultrasound signals attenuated by microbubbles
Is part of: Biomedical engineering 2014 : 18th international conference, 27-28 November, 2014, Kaunas, Lithuania, 2014, p. 71-75
Date: 2014
Keywords: Sonoporacija;Ultragarsas;Sonoporation;Ultrasound;Mikroburbulai;Microbubbles;Vaistų pernaša;Drug delivery;Dozimetrija;Dosimetry
Abstract: New dosimetric estimate for ultrasound and microbubble assissted molecular delivery method (sonoporation) is presented in current study. Ultrasound signals, attenuated by cavitating microbubbles, were quantified as amplitude vs. time integral – „AMP dose“. The latter metric accurately (R2=0.97) predicts irreversible sonoporation to CHO cells, induced by microbubble cavitation in vitro, and holds promising prospects for future applications to dosimetric evaluation of molecular delivery.
Appears in Collections:3. Konferencijų medžiaga / Conference materials

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