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Type of publication: Straipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)
Field of Science: Ekologija ir aplinkotyra / Ecology and environmental sciences (N012)
Author(s): Osorio-Yanez, Citlalli;Clemente, Diana B. P;Maitre, Léa;Vives-Usano, Martha;Bustamante, Mariona;Martinez, David;Casas, Maribe;Alexander, Jan;Thomsen, Cathrine;Chatzi, Leda;Gutzkow, Kristine B;Gražulevičienė, Regina;Martens, Dries S;Plusquin, Michelle;Slama, Rémy;McEachan, Rosemary R. C;Wright, John;Yang, Tiffany C;Urquiza, Jose;Tamayo, Ibon;Sunyer, Jordi;Vafeiadi, Marina;Nawrot, Tim S;Vrijheid, Martine
Title: Early life tobacco exposure and children’s telomere length: The HELIX project
Is part of: Science of the total environment. Amsterdam : Elsevier Science BV, 2020, vol. 711
Extent: p. 1-11
Date: 2020
Keywords: HELIX;Telemerai;DNR;Nėštumas;Tabako dūmų ekspozocija;Tobacco exposure;Leukocyte telomere length;Mitochondrial DNA content;Pregnancy;HELIX
Abstract: Telomere length and mitochondrial DNA content are considered biomarkers of cellular aging, oxidative stress, and inflammation, but there is almost no information on their association with tobacco smoke exposure in fetal and early life. The aim of this study was to assess whether prenatal and childhood tobacco exposure were associated with leukocyte telomere length (LTL) and mitochondrial DNA (mtDNA) content in children. As part of a multi-centre European birth cohort study HELIX (Human Early-Life Exposome) (n = 1396) we assessed maternal smoking status during pregnancy through questionnaires, and through urinary cotinine levels that were then used to classify women as not exposed to smoking (50 mu g/L). When the children were around 8 years of age (range: 5.4-12.0 years), childhood SHS tobacco smoke exposure was assessed through an extensive questionnaire and through measurements of urinary cotinine (3.03 mu g/L detected). Leukocyte mtDNA content and LTL were measured in the children at 8 years employing real time polymerase chain reaction (qPCR). Effect estimates were calculated using multivariate linear regression models for prenatal and childhood exposures adjusted for potential confounders. Maternal cotinine levels indicative of SHS exposure during pregnancy were associated with a decrease of 3.90% in LTL in children (95% CI: -6.68, -0.91), compared with nonsmoking, whereas the association for maternal cotinine levels indicative of active smoking did not reach statistical significance (-3.24%; 95% CI: -6.59, 0.21). Childhood SHS tobacco exposure was not associated with LTL in children. Global SHS exposure during childhood was associated with an increase of 3.51% (95% CI: 0.78, 6.27) in mtDNA content. Our findings suggest that tobacco smoke exposure during pregnancy, even at SHS levels, may accelerate telomere shortening in children and [...]
Affiliation(s): Aplinkotyros katedra
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

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