Please use this identifier to cite or link to this item:https://hdl.handle.net/20.500.12259/103001
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dc.contributor.authorClemente, Diana B. P-
dc.contributor.authorVrijheid, Martine-
dc.contributor.authorMartens, Dries S-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorDanilevičiutė, Asta-
dc.contributor.authorCastro, Montserrat de-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorGutzkow, Kristine B-
dc.contributor.authorLepeule, Johanna-
dc.contributor.authorMaitre, Léa-
dc.contributor.authorMcEachan, Rosie R.C-
dc.contributor.authorRobinson, Oliver-
dc.contributor.authorSchwarze, Per E-
dc.contributor.authorTamayo, Ibon-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorWright, John-
dc.contributor.authorSlama, Rémy-
dc.contributor.authorNieuwenhuijsen, Mark-
dc.contributor.authorNawrot, Tim S-
dc.coverage.spatialUS-
dc.date.accessioned2020-01-22T19:30:14Z-
dc.date.available2020-01-22T19:30:14Z-
dc.date.issued2019-
dc.identifier.issn00916765-
dc.identifier.otherVDU02-000062671-
dc.identifier.urihttps://ehp.niehs.nih.gov/doi/pdf/10.1289/EHP4148-
dc.identifier.urihttps://doi.org/10.1289/EHP4148-
dc.descriptionarticle no. 087001-
dc.description.abstractBACKGROUND: Telomere length is a molecular marker of biological aging. OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n= 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameter ≤2:5 lm (PM2:5), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. RESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2:5 exposures levels. Each standard deviation (SD) increase in prenatal NO2 was associated with a −1:5% (95% CI: −2:8, −0:2) change in LTL. Prenatal PM2:5 was nonsignificantly associated with LTL (−0:7% per SD increase; 95% CI: −2:0, 0.6). For each SD increment in 1-y childhood NO2 and PM2:5 exposure, LTL shortened by −1:6% (95% CI: −2:9, −0:4) and −1:4% (95% CI: −2:9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onwarden
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1-8-
dc.language.isoen-
dc.relation.ispartofEnvironmental health perspectives. Research Triangle Park, USA : National Institute of Environmental Health Sciences, 2019, Vol. 127, iss. 8-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyAcademic Search Premier (EBSCO)-
dc.relation.isreferencedbyMEDLINE-
dc.relation.isreferencedbyProQuest Central-
dc.relation.isreferencedbyAgriculture Collection (Gale)-
dc.relation.isreferencedbyScopus-
dc.subjectPregnancyen
dc.subjectRisken
dc.subjectHealthen
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titlePrenatal and childhood traffic-related air pollution exposure and telomere length in European children: the HELIX projecten
dc.typeStraipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)-
dc.identifier.doihttps://doi.org/10.1289/EHP4148-
dc.identifier.isiWOS:000483734400003-
dcterms.bibliographicCitation72-
dc.date.updated2020-05-19T08:47Z-
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item.fulltextWith Fulltext-
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crisitem.author.deptAplinkotyros katedra-
crisitem.author.deptAplinkotyros katedra-
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications
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