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dc.contributor.authorClemente, Diana B. P-
dc.contributor.authorVrijheid, Martine-
dc.contributor.authorMartens, Dries S-
dc.contributor.authorBustamante, Mariona-
dc.contributor.authorChatzi, Leda-
dc.contributor.authorDanilevičiutė, Asta-
dc.contributor.authorCastro, Montserrat de-
dc.contributor.authorGražulevičienė, Regina-
dc.contributor.authorGutzkow, Kristine B-
dc.contributor.authorLepeule, Johanna-
dc.contributor.authorMaitre, Léa-
dc.contributor.authorMcEachan, Rosie R.C-
dc.contributor.authorRobinson, Oliver-
dc.contributor.authorSchwarze, Per E-
dc.contributor.authorTamayo, Ibon-
dc.contributor.authorVafeiadi, Marina-
dc.contributor.authorWright, John-
dc.contributor.authorSlama, Rémy-
dc.contributor.authorNieuwenhuijsen, Mark-
dc.contributor.authorNawrot, Tim S-
dc.descriptionarticle no. 087001-
dc.description.abstractBACKGROUND: Telomere length is a molecular marker of biological aging. OBJECTIVE: Here we investigated whether early-life exposure to residential air pollution was associated with leukocyte telomere length (LTL) at 8 y of age. METHODS: In a multicenter European birth cohort study, HELIX (Human Early Life Exposome) (n= 1,396), we estimated prenatal and 1-y childhood exposure to nitrogen dioxide (NO2), particulate matter with aerodynamic diameter ≤2:5 lm (PM2:5), and proximity to major roads. Average relative LTL was measured using quantitative real-time polymerase chain reaction (qPCR). Effect estimates of the association between LTL and prenatal, 1-y childhood air pollution, and proximity to major roads were calculated using multiple linear mixed models with a random cohort effect and adjusted for relevant covariates. RESULTS: LTL was inversely associated with prenatal and 1-y childhood NO2 and PM2:5 exposures levels. Each standard deviation (SD) increase in prenatal NO2 was associated with a −1:5% (95% CI: −2:8, −0:2) change in LTL. Prenatal PM2:5 was nonsignificantly associated with LTL (−0:7% per SD increase; 95% CI: −2:0, 0.6). For each SD increment in 1-y childhood NO2 and PM2:5 exposure, LTL shortened by −1:6% (95% CI: −2:9, −0:4) and −1:4% (95% CI: −2:9, 0.1), respectively. Each doubling in residential distance to nearest major road during childhood was associated with a 1.6% (95% CI: 0.02, 3.1) lengthening in LTL. CONCLUSION: Lower exposures to air pollution during pregnancy and childhood were associated with longer telomeres in European children at 8 y of age. These results suggest that reductions in traffic-related air pollution may promote molecular longevity, as exemplified by telomere length, from early life onwarden
dc.description.sponsorshipAplinkotyros katedra-
dc.description.sponsorshipGamtos mokslų fakultetas-
dc.description.sponsorshipVytauto Didžiojo universitetas-
dc.format.extentp. 1-8-
dc.relation.ispartofEnvironmental health perspectives. Research Triangle Park, USA : National Institute of Environmental Health Sciences, 2019, Vol. 127, iss. 8-
dc.relation.isreferencedbyScience Citation Index Expanded (Web of Science)-
dc.relation.isreferencedbyAcademic Search Premier (EBSCO)-
dc.relation.isreferencedbyProQuest Central-
dc.relation.isreferencedbyAgriculture Collection (Gale)-
dc.subject.otherEkologija ir aplinkotyra / Ecology and environmental sciences (N012)-
dc.titlePrenatal and childhood traffic-related air pollution exposure and telomere length in European children: the HELIX projecten
dc.typeStraipsnis Clarivate Analytics Web of Science ar/ir Scopus / Article in Clarivate Analytics Web of Science or / and Scopus (S1)-
local.object{"source": {"code": "vdu", "handle": "62671"}, "publisher": {"name": "National Institute of Environmental Health Sciences", "list": false}, "db": {"clarivate": true, "scopus": true, "list": true}, "issn": ["0091-6765"], "doi": "10.1289/EHP4148", "code": "S1", "subject": ["N012"], "url": ["", ""], "country": "US", "language": "en", "area": "N", "original": true, "pages": 8, "sheets": 0.571, "timestamp": "20200519084728.0", "account": {"year": 2019, "late": false}, "na": 20, "nip": 19, "affiliation": [{"contribution": 0.05, "aip": 4, "country": ["ES", "BE", "ES", "ES"], "rel": "aut", "lname": "Clemente", "fname": "Diana B. P", "status": "0", "name": "Clemente, Diana B. P"}, {"contribution": 0.05, "aip": 3, "country": ["ES", "ES", "ES"], "rel": "aut", "lname": "Vrijheid", "fname": "Martine", "status": "0", "name": "Vrijheid, Martine"}, {"contribution": 0.05, "aip": 1, "country": ["BE"], "rel": "aut", "lname": "Martens", "fname": "Dries S", "status": "0", "name": "Martens, Dries S"}, {"contribution": 0.05, "aip": 3, "country": ["ES", "ES", "ES"], "rel": "aut", "lname": "Bustamante", "fname": "Mariona", "status": "0", "name": "Bustamante, Mariona"}, {"contribution": 0.05, "aip": 3, "country": ["US", "GR", "NL"], "rel": "aut", "lname": "Chatzi", "fname": "Leda", "status": "0", "name": "Chatzi, Leda"}, {"contribution": 0.05, "aip": 1, "country": ["LT"], "rel": "aut", "org": [{"create": true, "contribution": 0.05, "name": "Vytauto Didžiojo universitetas", "id": "111950396", "level": "0", "type": "uni", "research": "1", "status": "1", "unit": {"name": "Gamtos mokslų fakultetas", "id": "01", "level": "1", "type": "fak", "research": "1", "status": "1", "unit": {"name": "Aplinkotyros katedra", "id": "0101", "level": "2", "type": "kat", "research": "1", "status": "1"}}}], "id": "587AF4B22079C79A84463AE1937F5A8A", "lname": "Danilevičiūtė", "fname": "Asta", "status": "1", "orcid": "0000-0001-8304-6570", "name": "Danilevičiutė, Asta"}, {"contribution": 0.05, "aip": 3, "country": ["ES", "ES", "ES"], "rel": "aut", "lname": "Castro", "fname": "Montserrat de", "status": "0", "name": "Castro, Montserrat de"}, {"contribution": 0.05, "aip": 1, "country": ["LT"], "rel": "aut", "org": [{"create": true, "contribution": 0.05, "name": "Vytauto Didžiojo universitetas", "id": "111950396", "level": "0", "type": "uni", "research": "1", "status": "1", "unit": {"name": "Gamtos mokslų fakultetas", "id": "01", "level": "1", "type": "fak", "research": "1", "status": "1", "unit": {"name": "Aplinkotyros katedra", "id": "0101", "level": "2", "type": "kat", "research": "1", "status": "1"}}}], "id": "BEC162E4F9A5CE824E3A9C48E42E30CC", "lname": "Gražulevičienė", "fname": "Regina", "status": "1", "orcid": "0000-0002-0210-8053", "name": "Gražulevičienė, Regina"}, {"contribution": 0.05, "aip": 1, "country": ["NO"], "rel": "aut", "lname": "Gutzkow", "fname": "Kristine B", "status": "0", "name": "Gutzkow, Kristine B"}, {"contribution": 0.05, "aip": 1, "country": ["FR"], "rel": "aut", "lname": "Lepeule", "fname": "Johanna", "status": "0", "name": "Lepeule, Johanna"}, {"contribution": 0.05, "aip": 3, "country": ["ES", "ES", "ES"], "rel": "aut", "lname": "Maitre", "fname": "Léa", "status": "0", "name": "Maitre, Léa"}, {"contribution": 0.05, "aip": 1, "country": ["GB"], "rel": "aut", "lname": "McEachan", "fname": "Rosie R.C", "status": "0", "name": "McEachan, Rosie R.C"}, {"contribution": 0.05, "aip": 1, "country": ["GB"], "rel": "aut", "lname": "Robinson", "fname": "Oliver", "status": "0", "name": "Robinson, Oliver"}, {"contribution": 0.05, "aip": 1, "country": ["NO"], "rel": "aut", "lname": "Schwarze", "fname": "Per E", "status": "0", "name": "Schwarze, Per E"}, {"contribution": 0.05, "aip": 1, "country": ["US"], "rel": "aut", "lname": "Tamayo", "fname": "Ibon", "status": "0", "name": "Tamayo, Ibon"}, {"contribution": 0.05, "aip": 1, "country": ["GR"], "rel": "aut", "lname": "Vafeiadi", "fname": "Marina", "status": "0", "name": "Vafeiadi, Marina"}, {"contribution": 0.05, "aip": 1, "country": ["GB"], "rel": "aut", "lname": "Wright", "fname": "John", "status": "0", "name": "Wright, John"}, {"contribution": 0.05, "aip": 1, "country": ["GB"], "rel": "aut", "lname": "Slama", "fname": "Rémy", "status": "0", "name": "Slama, Rémy"}, {"contribution": 0.05, "aip": 3, "country": ["ES", "ES", "ES"], "rel": "aut", "lname": "Nieuwenhuijsen", "fname": "Mark", "status": "0", "name": "Nieuwenhuijsen, Mark"}, {"contribution": 0.05, "aip": 2, "country": ["BE", "BE"], "rel": "aut", "lname": "Nawrot", "fname": "Tim S", "status": "0", "name": "Nawrot, Tim S"}]}-
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