Please use this identifier to cite or link to this item:
Type of publication: research article
Type of publication (PDB): Straipsnis Clarivate Analytics Web of Science / Article in Clarivate Analytics Web of Science (S1)
Field of Science: Biologija / Biology (N010)
Author(s): Jurkonis, Rytis;Sakalauskas, Andrius;Lukoševičius, Arūnas;Maciulevičius, Martynas;Tamošiūnas, Mindaugas;Šatkauskas, Saulius
Title: Mapping microbubble and ultrasound spatio-temporal interaction by M-mode imaging: the study of feasibility
Is part of: Acoustical physics. Moscow: Pleiades publishing Ltd, 2019, Vol. 65, iss. 2
Extent: p. 216-225
Date: 2019
Keywords: Microbubble (MB) interaction;Ultrasonic imaging;Acoustical measurement methods;Biological media
Abstract: Ultrasound (US) and microbubble (MB) interaction is an important factor in the research of bioacoustics, as well as targeted drug and gene delivery. In this study, we demonstrate the feasibility of pulse−echo M-mode imaging system to be used for the visualization and quantification of US–MB interaction in both spatial and temporal dimensions. The system incorporates an exposure chamber with the cell– MB suspension, a 2.7 MHz focused US transducer, a US pulser–receiver and the customized LabView software. The results of cell and MB interaction obtained after M-mode image analysis have showed the US–MB interaction to be non-uniform in space and non-stationary in time. In order to quantify the spatio-temporal US–MB interaction, we have introduced the time function of spatial homogeneity dynamics. We have observed that the effective duration of interaction can be characterized at the predefined threshold of spatial homogeneity. For example, at the US excitation of 360 kPa peak negative pressure (15 bursts transmitted at 80 Hz pulse repetition frequency), the US–MB interaction persists for more than 5 seconds in the range at 4 mm depth of the exposure chamber with more than 50% of homogeneity. The system proposed in this assay is feasible for the characterization of US–MB interaction and can be exploited to optimize the MB concentration and/or the US excitation parameters
Affiliation(s): Biochemijos katedra
Biologijos katedra
Kauno technologijos universitetas
Vytauto Didžiojo universitetas
Appears in Collections:Universiteto mokslo publikacijos / University Research Publications

Files in This Item:
marc.xml7.47 kBXMLView/Open

MARC21 XML metadata

Show full item record
Export via OAI-PMH Interface in XML Formats
Export to Other Non-XML Formats

CORE Recommender

Citations 5

checked on Apr 24, 2021

Page view(s)

checked on May 1, 2021


checked on May 1, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.